Illustration of ladies in science drops considerably at every profession stage, from early scholar to senior investigator. Disparities in alternatives for girls to contribute to analysis metrics, akin to distinguished speaker occasions and authorship, have been reported in lots of fields in the united statesA. and Europe. Nevertheless, whether or not feminine illustration in scientific contributions differs in different areas, akin to Latin America, just isn’t nicely understood.
On this examine, with the intention to decide whether or not feminine authorship is influenced by gender or institutional location of the final (senior) creator or by subfield inside ecology, we gathered creator info from 6849 articles in ten ecological and zoological journals that publish analysis articles both in or out of Latin America. We discovered that feminine authorship has risen marginally since 2002 (27 to 31%), and varies amongst Latin American nations, however not between Latin America and different areas.
Final creator gender predicted feminine co-authorship throughout all journals and areas, as analysis teams led by ladies printed with over 60% feminine co-authors whereas these led by males printed with lower than 20% feminine co-authors. Our findings recommend that implicit biases and stereotype threats that girls face in male-led laboratories might be sources of feminine withdrawal and leaky pipelines in ecology and zoology. Accordingly, we encourage each PI to self-evaluate their lifetime share of feminine co-authors. Feminine position fashions and cultural shifts-especially by male senior authors-are essential for feminine retention and unbiased participation in science.
Time-Restricted Inquiry-Based mostly Studying Promotes Energetic Pupil Engagement in Undergraduate Zoology Laboratory.
Organizing a zoology laboratory for an undergraduate course is usually a problem, notably in a limited-resource setting, because of the huge number of matters to cowl and the restricted numbers of preserved specimens and everlasting slides. In zoology, the category construction typically takes the type of a lecture demonstration adopted by pattern exhibition stations. This setting typically fails to actively have interaction nearly all of college students in exploring the specimens.
Right here we suggest another group of a zoology class lab format comprised of brief guided-inquiry, time-restricted lab stations, and a freely structured follow-up challenge meant to extend consideration and conceptual understanding of the lab matter. The lab is designed in two components: a 10-minute in-class rotation portion, the place small teams of scholars take turns investigating specimens following an teacher demonstration, and an after-class group project.
We carried out the technique for 2 years, and it’s clear that our method considerably elevated college students’ lively engagement within the class. The time-restricted scheme ensures all college students take part regardless of restricted assets, whereas the guided directions hold the scholars targeted on the subject. Moreover, the crew project portion, particularly the media creation facet, promoted teamwork amongst group members.
Domesticated Animals on Exhibit on the Museum of Comparative Zoology, 1900-1928.
In 1905 the Museum of Comparative Zoology at Harvard College started planning for a brand new domesticated animals exhibition in honor of the 100th anniversary of the beginning of its founder Louis Agassiz. The ensuing shows of variation and heredity in poultry, pigeons, rabbits, mice, and guinea pigs proved surprisingly common to museumgoers. A few of these specimens nonetheless exist within the museum’s storage services, particularly a collection of poultry donated by the biologist Charles B.
Davenport and an elaborate set of guinea pigs from the experimental evolutionist William E. Citadel. Situating these domesticated animal shows inside educational and common cultures of poultry fancying, animal breeding, and evolutionary science reveals how a nineteenth-century museum identified for its ties to anti-evolutionary rules tried to modernize its public reveals.
Evolutionary computation in zoology and ecology.
Evolutionary computational strategies have adopted attributes of pure choice and evolution to unravel issues in laptop science, engineering, and different fields. The strategy is rising in use in zoology and ecology. Evolutionary rules could also be merged with an agent-based modeling perspective to have particular person animals or different brokers compete. 4 essential classes are mentioned: genetic algorithms, evolutionary programming, genetic programming, and evolutionary methods. In evolutionary computation, a inhabitants is represented in a means that permits for an goal operate to be assessed that’s related to the issue of curiosity.
The poorest performing members are faraway from the inhabitants, and remaining members reproduce and could also be mutated. The health of the members is once more assessed, and the cycle continues till a stopping situation is met. Case research embody optimizing: egg form given completely different clutch sizes, mate choice, migration of wildebeest, birds, and elk, vulture foraging habits, algal bloom prediction, and species richness given vitality constraints. Different case research simulate the evolution of species and a method to challenge shifts in species ranges in response to a altering local weather that features competitors and phenotypic plasticity.
17-DMAG, Hydrochloride Salt, >98% |
BC024-025 |
GenDepot |
25mg |
Ask for price |
17-DMAG, Hydrochloride Salt, >99% |
BC024-100 |
GenDepot |
100mg |
Ask for price |
17-DMAG, Hydrochloride Salt, >99% |
BC024-101 |
GenDepot |
1g |
Ask for price |
17-DMAG, Hydrochloride Salt, >99% |
BC024-250 |
GenDepot |
250mg |
Ask for price |
OSU-03012, Hydrochloride Salt, >98% |
BC061-005 |
GenDepot |
5mg |
EUR 375.6 |
OSU-03012, Hydrochloride Salt, >98% |
BC061-025 |
GenDepot |
25mg |
EUR 634.8 |
Tetracycline, Hydrochloride |
CH054 |
ABM |
25 g |
EUR 142.8 |
Tetracycline, Hydrochloride |
CH055 |
ABM |
100 g |
EUR 204 |
Ciprofloxacin hydrochloride |
C032-25G |
TOKU-E |
25 g |
EUR 199.2 |
Ciprofloxacin hydrochloride |
C032-5G |
TOKU-E |
5 g |
EUR 74.4 |
Clindamycin Hydrochloride |
C035-100MG |
TOKU-E |
100 mg |
EUR 243.6 |
Clindamycin Hydrochloride |
C035-50MG |
TOKU-E |
50 mg |
EUR 152.4 |
Chlortetracycline Hydrochloride |
C072-100G |
TOKU-E |
100 g |
EUR 376.8 |
Chlortetracycline Hydrochloride |
C072-25G |
TOKU-E |
25 g |
EUR 157.2 |
Chlortetracycline Hydrochloride |
C072-5G |
TOKU-E |
5 g |
EUR 78 |
Cefozopran Hydrochloride |
C099-100MG |
TOKU-E |
100 mg |
EUR 300 |
Cysteamine hydrochloride |
C212-25G |
TOKU-E |
25 g |
EUR 78 |
Cysteamine hydrochloride |
C212-4x25G |
TOKU-E |
4 x 25 g |
EUR 154.8 |
Ceftiofur Hydrochloride |
C228-1G |
TOKU-E |
1 g |
EUR 129.6 |
Ceftiofur Hydrochloride |
C228-5G |
TOKU-E |
5 g |
EUR 387.6 |
Cefmenoxime Hydrochloride |
C240-100MG |
TOKU-E |
100mg |
EUR 136.8 |
Cefmenoxime Hydrochloride |
C240-500MG |
TOKU-E |
500mg |
EUR 334.8 |
Cinacalcet Hydrochloride |
C242-100MG |
TOKU-E |
100mg |
EUR 513.6 |
Cinacalcet Hydrochloride |
C242-10MG |
TOKU-E |
10mg |
EUR 94.8 |
Enrofloxacin hydrochloride |
E007-100MG |
TOKU-E |
100 mg |
EUR 147.6 |
Enrofloxacin hydrochloride |
E007-1G |
TOKU-E |
1 g |
EUR 776.4 |
Enrofloxacin hydrochloride |
E007-500MG |
TOKU-E |
500 mg |
EUR 475.2 |
Erlotinib hydrochloride |
E017-100MG |
TOKU-E |
100 mg |
EUR 136.8 |
Erlotinib hydrochloride |
E017-1G |
TOKU-E |
1 g |
EUR 373.2 |
Pazopanib Hydrochloride |
A8347-100 |
ApexBio |
100 mg |
EUR 268.8 |
Description: Pazopanib HCl is a receptor tyrosine kinase inhibitor that targets multiple kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit, and c-Fms, with IC50s 10nM, 30nM, 47nM, 84nM, 74nM, 140nM, and 146nM respectively [1-3]. |
Pazopanib Hydrochloride |
A8347-25 |
ApexBio |
25 mg |
EUR 129.6 |
Description: Pazopanib HCl is a receptor tyrosine kinase inhibitor that targets multiple kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit, and c-Fms, with IC50s 10nM, 30nM, 47nM, 84nM, 74nM, 140nM, and 146nM respectively [1-3]. |
Pazopanib Hydrochloride |
A8347-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 135.6 |
Description: Pazopanib HCl is a receptor tyrosine kinase inhibitor that targets multiple kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit, and c-Fms, with IC50s 10nM, 30nM, 47nM, 84nM, 74nM, 140nM, and 146nM respectively [1-3]. |
Pazopanib Hydrochloride |
A8347-500 |
ApexBio |
500 mg |
EUR 727.2 |
Description: Pazopanib HCl is a receptor tyrosine kinase inhibitor that targets multiple kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit, and c-Fms, with IC50s 10nM, 30nM, 47nM, 84nM, 74nM, 140nM, and 146nM respectively [1-3]. |
Pazopanib Hydrochloride |
A8347-S |
ApexBio |
Evaluation Sample |
EUR 97.2 |
Description: Pazopanib HCl is a receptor tyrosine kinase inhibitor that targets multiple kinases, including VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit, and c-Fms, with IC50s 10nM, 30nM, 47nM, 84nM, 74nM, 140nM, and 146nM respectively [1-3]. |
Bestatin hydrochloride |
A8621-10 |
ApexBio |
10 mg |
EUR 157.2 |
Description: Bestatin hydrochloride, also known as Ubenimex, is an inhibitor of aminopeptidase B and N (APN)/CD13 [1].Bestatin, an antibiotic of microbial origin, is a potent inhibitor of some aminopeptidases which can be administered to cultured cells, intact animals and humans with low toxicity. |
Bestatin hydrochloride |
A8621-100 |
ApexBio |
100 mg |
EUR 532.8 |
Description: Bestatin hydrochloride, also known as Ubenimex, is an inhibitor of aminopeptidase B and N (APN)/CD13 [1].Bestatin, an antibiotic of microbial origin, is a potent inhibitor of some aminopeptidases which can be administered to cultured cells, intact animals and humans with low toxicity. |
Bestatin hydrochloride |
A8621-25 |
ApexBio |
25 mg |
EUR 226.8 |
Description: Bestatin hydrochloride, also known as Ubenimex, is an inhibitor of aminopeptidase B and N (APN)/CD13 [1].Bestatin, an antibiotic of microbial origin, is a potent inhibitor of some aminopeptidases which can be administered to cultured cells, intact animals and humans with low toxicity. |
Bestatin hydrochloride |
A8621-5 |
ApexBio |
5 mg |
EUR 129.6 |
Description: Bestatin hydrochloride, also known as Ubenimex, is an inhibitor of aminopeptidase B and N (APN)/CD13 [1].Bestatin, an antibiotic of microbial origin, is a potent inhibitor of some aminopeptidases which can be administered to cultured cells, intact animals and humans with low toxicity. |
Flavopiridol hydrochloride |
A8640-10 |
ApexBio |
10 mg |
EUR 129.6 |
Description: Flavopiridol hydrochloride is a selective inhibitor of CDK1, CDK2, CDK4 and CDK6 with IC50 value all ~41 nM as well as CDK7 with 300nM [1] [2] [3].CDKs are protein kinase families which involve in the process of regulating transcription, mRNA processing, cell differentiation and cell cycle. |
Flavopiridol hydrochloride |
A8640-100 |
ApexBio |
100 mg |
EUR 528 |
Description: Flavopiridol hydrochloride is a selective inhibitor of CDK1, CDK2, CDK4 and CDK6 with IC50 value all ~41 nM as well as CDK7 with 300nM [1] [2] [3].CDKs are protein kinase families which involve in the process of regulating transcription, mRNA processing, cell differentiation and cell cycle. |
Flavopiridol hydrochloride |
A8640-1000 |
ApexBio |
1 g |
EUR 3259.2 |
Description: Flavopiridol hydrochloride is a selective inhibitor of CDK1, CDK2, CDK4 and CDK6 with IC50 value all ~41 nM as well as CDK7 with 300nM [1] [2] [3].CDKs are protein kinase families which involve in the process of regulating transcription, mRNA processing, cell differentiation and cell cycle. |
Flavopiridol hydrochloride |
A8640-25 |
ApexBio |
25 mg |
EUR 199.2 |
Description: Flavopiridol hydrochloride is a selective inhibitor of CDK1, CDK2, CDK4 and CDK6 with IC50 value all ~41 nM as well as CDK7 with 300nM [1] [2] [3].CDKs are protein kinase families which involve in the process of regulating transcription, mRNA processing, cell differentiation and cell cycle. |
Flavopiridol hydrochloride |
A8640-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 129.6 |
Description: Flavopiridol hydrochloride is a selective inhibitor of CDK1, CDK2, CDK4 and CDK6 with IC50 value all ~41 nM as well as CDK7 with 300nM [1] [2] [3].CDKs are protein kinase families which involve in the process of regulating transcription, mRNA processing, cell differentiation and cell cycle. |
Regorafenib hydrochloride |
A3750-10 |
ApexBio |
10 mg |
EUR 150 |
Description: Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. |
Regorafenib hydrochloride |
A3750-100 |
ApexBio |
100 mg |
EUR 282 |
Description: Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. |
Regorafenib hydrochloride |
A3750-200 |
ApexBio |
200 mg |
EUR 582 |
Description: Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. |
Regorafenib hydrochloride |
A3750-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 199.2 |
Description: Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. |
Regorafenib hydrochloride |
A3750-50 |
ApexBio |
50 mg |
EUR 199.2 |
Description: Regorafenib (BAY 73-4506) is a multikinase inhibitor with IC50 of 17, 40 and 69 nM c-KIT, VEGFR2, B-Raf. |
Resminostat hydrochloride |
A3755-10 |
ApexBio |
10 mg |
EUR 428.4 |
Description: Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6 [1]. |
Resminostat hydrochloride |
A3755-100 |
ApexBio |
100 mg |
EUR 1905.6 |
Description: Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6 [1]. |
Resminostat hydrochloride |
A3755-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 464.4 |
Description: Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6 [1]. |
Resminostat hydrochloride |
A3755-50 |
ApexBio |
50 mg |
EUR 1209.6 |
Description: Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6 [1]. |
Rimonabant hydrochloride |
A3766-10 |
ApexBio |
10 mg |
EUR 186 |
Description: Rimonabant, also known as SR141716, was the first selective central cannabinoid (CB1) receptor inverse agonist (Ki = 1.8 nM) to be developed as an appetite suppressant, anti-obesity drug. |
Rimonabant hydrochloride |
A3766-100 |
ApexBio |
100 mg |
EUR 710.4 |
Description: Rimonabant, also known as SR141716, was the first selective central cannabinoid (CB1) receptor inverse agonist (Ki = 1.8 nM) to be developed as an appetite suppressant, anti-obesity drug. |
Rimonabant hydrochloride |
A3766-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 199.2 |
Description: Rimonabant, also known as SR141716, was the first selective central cannabinoid (CB1) receptor inverse agonist (Ki = 1.8 nM) to be developed as an appetite suppressant, anti-obesity drug. |
Rimonabant hydrochloride |
A3766-50 |
ApexBio |
50 mg |
EUR 494.4 |
Description: Rimonabant, also known as SR141716, was the first selective central cannabinoid (CB1) receptor inverse agonist (Ki = 1.8 nM) to be developed as an appetite suppressant, anti-obesity drug. |
Rotigotine hydrochloride |
A3777-100 |
ApexBio |
100 mg |
EUR 480 |
Description: Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic ?2B receptors. Rotigotine exhibits antiparkinsonian acitivity. |
Rotigotine hydrochloride |
A3777-200 |
ApexBio |
200 mg |
EUR 812.4 |
Description: Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic ?2B receptors. Rotigotine exhibits antiparkinsonian acitivity. |
Rotigotine hydrochloride |
A3777-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 417.6 |
Description: Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic ?2B receptors. Rotigotine exhibits antiparkinsonian acitivity. |
Rotigotine hydrochloride |
A3777-50 |
ApexBio |
50 mg |
EUR 360 |
Description: Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic ?2B receptors. Rotigotine exhibits antiparkinsonian acitivity. |
Rotigotine hydrochloride |
A3777-500 |
ApexBio |
500 mg |
EUR 1663.2 |
Description: Rotigotine is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively. Rotigotine also has significant affinity for 5-HT1A and adrenergic ?2B receptors. Rotigotine exhibits antiparkinsonian acitivity. |
Tipiracil hydrochloride |
A3875-10 |
ApexBio |
10 mg |
EUR 553.2 |
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway. |
Tipiracil hydrochloride |
A3875-25 |
ApexBio |
25 mg |
EUR 774 |
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway. |
Tipiracil hydrochloride |
A3875-5 |
ApexBio |
5 mg |
EUR 382.8 |
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway. |
Tipiracil hydrochloride |
A3875-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 351.6 |
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway. |
Tipiracil hydrochloride |
A3875-50 |
ApexBio |
50 mg |
EUR 1230 |
Description: Tipiracil is an inhibitor of Thymidine phosphorylase (TP). Thymidine phosphorylase (TP)is a key enzyme in the pyrimidine nucleoside salvage pathway. |
Vandetanib hydrochloride |
A3906-100 |
ApexBio |
100 mg |
EUR 517.2 |
Description: Description: IC50 Value: 40 nM (VEGFR2) [1]; 500 nM (EGFR) [2] Vandetanib is an anti-cancer drug that is used for the treatment of certain tumours of thethyroid gland. |
Vandetanib hydrochloride |
A3906-25 |
ApexBio |
25 mg |
EUR 201.6 |
Description: Description: IC50 Value: 40 nM (VEGFR2) [1]; 500 nM (EGFR) [2] Vandetanib is an anti-cancer drug that is used for the treatment of certain tumours of thethyroid gland. |
Vernakalant Hydrochloride |
A3915-10 |
ApexBio |
10 mg |
EUR 847.2 |
Description: IC50: Vernakalant inhibits two specific potassium currents, IKur (IC50 = 9 ??) and IKACh (IC50=10 ?M) which are only present in atrial myocardium [1].Vernakalant blocks atrial potassium channels, thereby prolonging repolarization. |
Vernakalant Hydrochloride |
A3915-100 |
ApexBio |
100 mg |
EUR 3316.8 |
Description: IC50: Vernakalant inhibits two specific potassium currents, IKur (IC50 = 9 ??) and IKACh (IC50=10 ?M) which are only present in atrial myocardium [1].Vernakalant blocks atrial potassium channels, thereby prolonging repolarization. |
Vernakalant Hydrochloride |
A3915-50 |
ApexBio |
50 mg |
EUR 2090.4 |
Description: IC50: Vernakalant inhibits two specific potassium currents, IKur (IC50 = 9 ??) and IKACh (IC50=10 ?M) which are only present in atrial myocardium [1].Vernakalant blocks atrial potassium channels, thereby prolonging repolarization. |
Vilazodone Hydrochloride |
A3919-10 |
ApexBio |
10 mg |
EUR 129.6 |
Description: Vilazodone (EMD 68843; SB 659746A; 5-{4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide hydrochloride) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. |
Vilazodone Hydrochloride |
A3919-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 129.6 |
Description: Vilazodone (EMD 68843; SB 659746A; 5-{4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide hydrochloride) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. |
Vilazodone Hydrochloride |
A3919-50 |
ApexBio |
50 mg |
EUR 157.2 |
Description: Vilazodone (EMD 68843; SB 659746A; 5-{4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl}-benzofuran-2-carboxamide hydrochloride) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. |
Voreloxin Hydrochloride |
A3925-10 |
ApexBio |
10 mg |
EUR 895.2 |
Description: Voreloxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. |
Voreloxin Hydrochloride |
A3925-5 |
ApexBio |
5 mg |
EUR 656.4 |
Description: Voreloxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. |
Voreloxin Hydrochloride |
A3925-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 717.6 |
Description: Voreloxin is a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. |
PJ34 hydrochloride |
A4159-10 |
ApexBio |
10 mg |
EUR 142.8 |
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM. |
PJ34 hydrochloride |
A4159-5 |
ApexBio |
5 mg |
EUR 129.6 |
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM. |
PJ34 hydrochloride |
A4159-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 150 |
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM. |
PJ34 hydrochloride |
A4159-50 |
ApexBio |
50 mg |
EUR 296.4 |
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM. |
PJ34 hydrochloride |
A4159-S |
ApexBio |
Evaluation Sample |
EUR 97.2 |
Description: PJ34 is a novel and potent inhibitor of poly(ADP-ribose) polymerase (PARP), an enzyme involved in DNA repair and cell proliferation, that dose-dependently inhibits purified PARP enzyme in a cell-free assay with half maximal effective concentration EC50 value of 20 nM. |
Dimethylamine hydrochloride |
DB0410 |
Bio Basic |
500g |
EUR 116.38 |
|
Daunorubicin hydrochloride |
D001-10MG |
TOKU-E |
10 mg |
EUR 142.8 |
Daunorubicin hydrochloride |
D001-50MG |
TOKU-E |
50 mg |
EUR 480 |
Difloxacin hydrochloride |
D021-1G |
TOKU-E |
1 g |
EUR 133.2 |
Difloxacin hydrochloride |
D021-5G |
TOKU-E |
5 g |
EUR 438 |
Demeclocycline hydrochloride |
D032-1G |
TOKU-E |
1 g |
EUR 208.8 |
Demeclocycline hydrochloride |
D032-250MG |
TOKU-E |
250 mg |
EUR 105.6 |
Demeclocycline hydrochloride |
D032-5G |
TOKU-E |
5 g |
EUR 646.8 |
Doxycycline Hydrochloride |
D065-25MG |
TOKU-E |
25mg |
EUR 410.4 |
Doxycycline Hydrochloride |
D065-5MG |
TOKU-E |
5mg |
EUR 142.8 |
Dalbavancin Hydrochloride |
D092-10MG |
TOKU-E |
10mg |
EUR 152.4 |
Dalbavancin Hydrochloride |
D092-50MG |
TOKU-E |
50mg |
EUR 456 |
Cefepime Hydrochloride |
C009-100MG |
TOKU-E |
100 mg |
EUR 320.4 |
Ceftazidime Hydrochloride |
C020-1G |
TOKU-E |
1 g |
EUR 746.4 |
Niguldipine (hydrochloride) |
C3067-10 |
ApexBio |
10 mg |
EUR 164.4 |
Description: Ki = 0.16 nM: ?1A-adrenoceptor antagonistIC50s = 0.4 ?M: inhibits L-type Ca2+ channelsIC50s = 0.9 ?M: suppresses T-type Ca2+ channelsNiguldipine is a less potent Ca2+ channel blocker and potent, selective ?1A-adrenoceptor receptor antagonist. |
Niguldipine (hydrochloride) |
C3067-25 |
ApexBio |
25 mg |
EUR 308.4 |
Description: Ki = 0.16 nM: ?1A-adrenoceptor antagonistIC50s = 0.4 ?M: inhibits L-type Ca2+ channelsIC50s = 0.9 ?M: suppresses T-type Ca2+ channelsNiguldipine is a less potent Ca2+ channel blocker and potent, selective ?1A-adrenoceptor receptor antagonist. |
AD57 (hydrochloride) |
C3080-1 |
ApexBio |
1 mg |
EUR 141.6 |
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer. |
AD57 (hydrochloride) |
C3080-10 |
ApexBio |
10 mg |
EUR 714 |
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer. |
AD57 (hydrochloride) |
C3080-5 |
ApexBio |
5 mg |
EUR 428.4 |
Description: IC50: 2 nM: blocks the receptor tyrosine kinase RET in Drosophila.AD57, as a polypharmacological cancer therapeutic, is designed to regulate multiple targets related to cancer. |
Pargyline (hydrochloride) |
C3106-1000 |
ApexBio |
1 g |
EUR 139.2 |
Description: IC50: 11.52 nM: inhibits monoamine oxidase (MAO) type A (MAO-A).IC50: 8.2 nM: blocks MAO type B (MAO-B).Pargyline, an irreversible and non-selective inhibitor of MAO, is used to treat moderate hypertension and cancer cells. |
Pargyline (hydrochloride) |
C3106-5000 |
ApexBio |
5 g |
EUR 410.4 |
Description: IC50: 11.52 nM: inhibits monoamine oxidase (MAO) type A (MAO-A).IC50: 8.2 nM: blocks MAO type B (MAO-B).Pargyline, an irreversible and non-selective inhibitor of MAO, is used to treat moderate hypertension and cancer cells. |
Clenbuterol (hydrochloride) |
C3119-100 |
ApexBio |
100 mg |
EUR 258 |
Description: Clenbuterol is a sympathomimetic ?2-adrenoceptor agonist. ?2-adrenoceptor agonists, mainly long-acting ?2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease. |
Clenbuterol (hydrochloride) |
C3119-25 |
ApexBio |
25 mg |
EUR 130.8 |
Description: Clenbuterol is a sympathomimetic ?2-adrenoceptor agonist. ?2-adrenoceptor agonists, mainly long-acting ?2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease. |
Clenbuterol (hydrochloride) |
C3119-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 135.6 |
Description: Clenbuterol is a sympathomimetic ?2-adrenoceptor agonist. ?2-adrenoceptor agonists, mainly long-acting ?2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease. |
Clenbuterol (hydrochloride) |
C3119-50 |
ApexBio |
50 mg |
EUR 189.6 |
Description: Clenbuterol is a sympathomimetic ?2-adrenoceptor agonist. ?2-adrenoceptor agonists, mainly long-acting ?2-adrenoceptor agonists, are an important pharmacological approach to induce bronchodilation in patients with chronic obstructive pulmonary disease. |
CBL0137 (hydrochloride) |
C3192-10 |
ApexBio |
10 mg |
EUR 529.2 |
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B. |
CBL0137 (hydrochloride) |
C3192-25 |
ApexBio |
25 mg |
EUR 1071.6 |
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B. |
CBL0137 (hydrochloride) |
C3192-5 |
ApexBio |
5 mg |
EUR 331.2 |
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B. |
CBL0137 (hydrochloride) |
C3192-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 282 |
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B. |
CBL0137 (hydrochloride) |
C3192-50 |
ApexBio |
50 mg |
EUR 1851.6 |
Description: EC50: 0.37 ?M for activating p53; 0.47 ?M for inhibiting NF-?B CBL0137 (hydrochloride) is a curaxin that activates p53 and inhibits NF-?B. |
CPTH2 (hydrochloride) |
C3208-10 |
ApexBio |
10 mg |
EUR 231.6 |
Description: CPTH2 is an inhibitor of HAT activity of Gcn5. |
CPTH2 (hydrochloride) |
C3208-5 |
ApexBio |
5 mg |
EUR 192 |
Description: CPTH2 is an inhibitor of HAT activity of Gcn5. |
Clinafloxacin (hydrochloride) |
C3345-100 |
ApexBio |
100 mg |
EUR 184.8 |
Description: Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. Clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections. |
Clinafloxacin (hydrochloride) |
C3345-1000 |
ApexBio |
1 g |
EUR 686.4 |
Description: Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. Clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections. |
Clinafloxacin (hydrochloride) |
C3345-250 |
ApexBio |
250 mg |
EUR 309.6 |
Description: Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. Clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections. |
Clinafloxacin (hydrochloride) |
C3345-500 |
ApexBio |
500 mg |
EUR 459.6 |
Description: Clinafloxacin is a broad-spectrum antibiotic of the quinolone carboxylic acid category that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumonia. Clinafloxacin, a fluoroquinolone, is currently in development for oral and intravenous therapy of serious infections. |
Isoxsuprine (hydrochloride) |
C3347-10000 |
ApexBio |
10 g |
EUR 145.2 |
Description: Isoxsuprine is a modulator of ?2 adrenoreceptor and has agonist or antagonist effects.The ?2 adrenoceptors are a class of G protein-coupled receptors that are targets for epinephrine. |
Isoxsuprine (hydrochloride) |
C3347-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 135.6 |
Description: Isoxsuprine is a modulator of ?2 adrenoreceptor and has agonist or antagonist effects.The ?2 adrenoceptors are a class of G protein-coupled receptors that are targets for epinephrine. |
DAPI (hydrochloride) |
C3362-10 |
ApexBio |
10 mg |
EUR 146.4 |
DAPI (hydrochloride) |
C3362-25 |
ApexBio |
25 mg |
EUR 240 |
DAPI (hydrochloride) |
C3362-5 |
ApexBio |
5 mg |
EUR 111.6 |
Kanosamine (hydrochloride) |
C3461-10 |
ApexBio |
10 mg |
EUR 528 |
Description: Kanosamine is the antibiotic produced by Bacillus cereus UW85. Kanosamine showed highly inhibitory effects to the growth of plant-pathogenic oomycetes and moderately inhibitory effects to certain fungi and inhibited few bacterial species tested. |
Kanosamine (hydrochloride) |
C3461-25 |
ApexBio |
25 mg |
EUR 1089.6 |
Description: Kanosamine is the antibiotic produced by Bacillus cereus UW85. Kanosamine showed highly inhibitory effects to the growth of plant-pathogenic oomycetes and moderately inhibitory effects to certain fungi and inhibited few bacterial species tested. |
Kanosamine (hydrochloride) |
C3461-5 |
ApexBio |
5 mg |
EUR 324 |
Description: Kanosamine is the antibiotic produced by Bacillus cereus UW85. Kanosamine showed highly inhibitory effects to the growth of plant-pathogenic oomycetes and moderately inhibitory effects to certain fungi and inhibited few bacterial species tested. |
Zoniporide (hydrochloride) |
C3480-10 |
ApexBio |
10 mg |
EUR 278.4 |
Description: Zoniporide (hydrochloride) is a novel, potent, and selective sodium-hydrogen exchanger isoform-1 (NHE-1) inhibitor [1]. The Na+/H+ exchanger (NHE) has been involved in intracellular pH homeostasis of many mammalian cell types. |
Zoniporide (hydrochloride) |
C3480-5 |
ApexBio |
5 mg |
EUR 181.2 |
Description: Zoniporide (hydrochloride) is a novel, potent, and selective sodium-hydrogen exchanger isoform-1 (NHE-1) inhibitor [1]. The Na+/H+ exchanger (NHE) has been involved in intracellular pH homeostasis of many mammalian cell types. |
Zoniporide (hydrochloride) |
C3480-50 |
ApexBio |
50 mg |
EUR 1004.4 |
Description: Zoniporide (hydrochloride) is a novel, potent, and selective sodium-hydrogen exchanger isoform-1 (NHE-1) inhibitor [1]. The Na+/H+ exchanger (NHE) has been involved in intracellular pH homeostasis of many mammalian cell types. |
MS023 (hydrochloride) |
C3503-1 |
ApexBio |
1 mg |
EUR 134.4 |
Description: IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectivelyMS023 is a type I PRMT inhibitor. Protein arginine methyltransferases (PRMTs) play a critical role in various biological processes. |
MS023 (hydrochloride) |
C3503-10 |
ApexBio |
10 mg |
EUR 661.2 |
Description: IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectivelyMS023 is a type I PRMT inhibitor. Protein arginine methyltransferases (PRMTs) play a critical role in various biological processes. |
MS023 (hydrochloride) |
C3503-25 |
ApexBio |
25 mg |
EUR 1375.2 |
Description: IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectivelyMS023 is a type I PRMT inhibitor. Protein arginine methyltransferases (PRMTs) play a critical role in various biological processes. |
MS023 (hydrochloride) |
C3503-5 |
ApexBio |
5 mg |
EUR 398.4 |
Description: IC50: 20, 119, 83, 8, and 8 nM for PRMT1, 3, 4, 6, and 8, respectivelyMS023 is a type I PRMT inhibitor. Protein arginine methyltransferases (PRMTs) play a critical role in various biological processes. |
Chlorprothixene (hydrochloride) |
C3509-1000 |
ApexBio |
1 g |
EUR 103.2 |
Description: Chlorprothixene (hydrochloride) is an antagonist of dopamine receptor and histamine receptors [1]. Chlorprothixene is also an inhibitor of GABAA receptor [2]. All of these three receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory and learning. |
Chlorprothixene (hydrochloride) |
C3509-10000 |
ApexBio |
10 g |
EUR 397.2 |
Description: Chlorprothixene (hydrochloride) is an antagonist of dopamine receptor and histamine receptors [1]. Chlorprothixene is also an inhibitor of GABAA receptor [2]. All of these three receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory and learning. |
Chlorprothixene (hydrochloride) |
C3509-25000 |
ApexBio |
25 g |
EUR 796.8 |
Description: Chlorprothixene (hydrochloride) is an antagonist of dopamine receptor and histamine receptors [1]. Chlorprothixene is also an inhibitor of GABAA receptor [2]. All of these three receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory and learning. |
Chlorprothixene (hydrochloride) |
C3509-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 135.6 |
Description: Chlorprothixene (hydrochloride) is an antagonist of dopamine receptor and histamine receptors [1]. Chlorprothixene is also an inhibitor of GABAA receptor [2]. All of these three receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory and learning. |
Chlorprothixene (hydrochloride) |
C3509-5000 |
ApexBio |
5 g |
EUR 249.6 |
Description: Chlorprothixene (hydrochloride) is an antagonist of dopamine receptor and histamine receptors [1]. Chlorprothixene is also an inhibitor of GABAA receptor [2]. All of these three receptors are implicated in many neurological processes, including motivation, pleasure, cognition, memory and learning. |
Cycloguanil (hydrochloride) |
C5763-10 |
ApexBio |
10 mg |
EUR 130.8 |
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid. |
Cycloguanil (hydrochloride) |
C5763-25 |
ApexBio |
25 mg |
EUR 195.6 |
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid. |
Cycloguanil (hydrochloride) |
C5763-50 |
ApexBio |
50 mg |
EUR 247.2 |
Description: Cycloguanil is an inhibitor of dihydrofolate reductase (DHFR)[1].Dihydrofolate reductase (DHFR) is an enzyme that involved in reducing dihydrofolic acid to tetrahydrofolic acid. |
Bufuralol (hydrochloride) |
C5043-1 |
ApexBio |
1 mg |
EUR 166.8 |
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing. |
Bufuralol (hydrochloride) |
C5043-10 |
ApexBio |
10 mg |
EUR 753.6 |
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing. |
Bufuralol (hydrochloride) |
C5043-5 |
ApexBio |
5 mg |
EUR 548.4 |
Description: Bufuralol is a non-specific ?-adrenergic blocker. Beta adrenergic agonists are medications relaxing muscles of the airways, which widens the airways and leads to easier breathing. |
AN3365 (hydrochloride) |
C5068-10 |
ApexBio |
10 mg |
EUR 393.6 |
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family. |
AN3365 (hydrochloride) |
C5068-25 |
ApexBio |
25 mg |
EUR 790.8 |
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family. |
AN3365 (hydrochloride) |
C5068-5 |
ApexBio |
5 mg |
EUR 247.2 |
Description: AN3365 is a potent and selective leucyl-tRNA synthetase inhibitor [1].The leucyl-tRNA synthetase belongs to a member of the class I aminoacyl-tRNA synthetase family. |
Calindol (hydrochloride) |
C5329-10 |
ApexBio |
10 mg |
EUR 528 |
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis. |
Calindol (hydrochloride) |
C5329-25 |
ApexBio |
25 mg |
EUR 1082.4 |
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis. |
Calindol (hydrochloride) |
C5329-5 |
ApexBio |
5 mg |
EUR 324 |
Description: Calindol is an activator of the calcium-sensing receptor (CaSR).The extracellular calciumsensing receptor (CaSR), a G protein-coupled receptor (GPCR), senses extracellular calcium[Ca2+]e and regulates calciumion homeostasis. |
Kasugamycin (hydrochloride) |
C5503-10000 |
ApexBio |
10 g |
EUR 420 |
Description: Kasugamycin is an aminoglycosidic antibiotic. Aminoglycoside, a medicinal and bacteriologic category of traditional Gram-negative antibacterial therapeutic agent, inhibits protein synthesis and contains as a portion of the molecule an amino-modified glycoside. |
Kasugamycin (hydrochloride) |
C5503-5000 |
ApexBio |
5 g |
EUR 301.2 |
Description: Kasugamycin is an aminoglycosidic antibiotic. Aminoglycoside, a medicinal and bacteriologic category of traditional Gram-negative antibacterial therapeutic agent, inhibits protein synthesis and contains as a portion of the molecule an amino-modified glycoside. |
Ciprofloxacin (hydrochloride) |
C5539-10000 |
ApexBio |
10 g |
EUR 139.2 |
Description: Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1]. |
Ciprofloxacin (hydrochloride) |
C5539-25000 |
ApexBio |
25 g |
EUR 184.8 |
Description: Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1]. |
Ciprofloxacin (hydrochloride) |
C5539-50000 |
ApexBio |
50 g |
EUR 268.8 |
Description: Ciprofloxacin (hydrochloride) is a fluoroquinolone antibiotic that has antimicrobial and immunomodulatory activities [1]. |
Fendiline (hydrochloride) |
C5675-5000 |
ApexBio |
5 g |
EUR 146.4 |
Description: Fendiline is an ?2-adrenergic receptor antagonist and L-type calcium channel blocker [1,2].The ?2 adrenergic receptor is a G protein-coupled receptor (GPCR). Until now, three different ?2-receptor subtypes have been identified: ?2A, ?2B, and ?2C. |
Moxifloxacin hydrochloride |
E1KS1465 |
EnoGene |
50mg |
EUR 296.4 |
(±)-Salsolinol (hydrochloride) |
C4364-500 |
ApexBio |
500 mg |
EUR 369.6 |
Description: (±)-Salsolinol targets depolarize dopamineric neurons. Dopaminergic neurons produce dopamine, a neurotransmitter with various roles in neurological functions. |
Midodrine (hydrochloride) |
C4493-100 |
ApexBio |
100 mg |
EUR 135.6 |
Description: Ki: 2, 6.9, and 1.7 ?M for ?1A, ?1B, ?1D, respectivelyMidodrine is the prodrug of the ?1-adrenergic receptor agonist, 1-(2?,5?-dimethoxyphenyl)-2-aminoethanol. |
This introduction concludes by citing different makes use of of evolutionary computation and a assessment of the pliability of the strategies. For instance, representing species’ area of interest areas topic to selective strain permits research on cladistics, the taxon cycle, impartial versus area of interest paradigms, elementary versus realized niches, neighborhood construction and order of colonization, invasiveness, and responses to a altering local weather.